What drugs interact with tizanidine? (2023)

When should you not take tizanidine?

You should not use tizanidine if you are allergic to it, or if: you also take the antidepressant fluvoxamine (Luvox); or. you also take the antibiotic ciprofloxacin (Cipro).

Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

Interactions between your drugs

No interactions were found between tizanidine and Tylenol.

You shouldn't take tizanidine (Zanaflex) if you take either fluvoxamine or ciprofloxacin. These two medications can cause this side effect to be dangerous. Low blood pressure from tizanidine (Zanaflex) can also happen if you stand up too fast, especially if you've been lying down.

This medicine may cause dizziness, drowsiness, lightheadedness, clumsiness or unsteadiness, or vision problems in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see well.

Tizanidine belongs to a class of drugs called central alpha-2 adrenergic receptor agonists . It is a fast-acting muscle relaxant that doctors commonly prescribe to help manage muscle spasticity.

Muscle relaxers work to alleviate muscle spasms and pain. Five of the most common muscle relaxers prescribed are carisoprodol, cyclobenzaprine, diazepam, metaxalone, and methocarbamol.

Ibuprofen (trade names are Advil, Motrin, Midol) "targets inflammation, so it is particularly helpful for muscle pain, joint pain and sports injuries.

Effects on the heart warning: This drug may cause heart arrhythmias (heart rate or rhythm problems). Your risk may be higher if you take a drug to treat depression or if you already have heart problems.

We consider that tizanidine has direct effects on the induction of sleep, and promotes muscular relaxation bringing about good sleep. We conclude that tizanidine is useful for the treatment of refractory sleep disturbance in spastic quadriplegic patients.

What painkiller can I take with tizanidine?

Ibuprofen 600mg mg + tizanidine 2-4mg every 8 hours, as needed for low back pain, x 7 days.

The commonly used muscle relaxant tizanidine can lower blood pressure. Tizanidine is metabolized by the enzyme CYP1A2, and concurrent use of tizanidine and a CYP1A2 inhibitor, such as ciprofloxacin, greatly increases tizanidine plasma concentrations.

Tizanidine relaxes muscles by dampening down nerve impulses that are sent from spasming muscles along nerve fibers to the brain.

Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine.

Similar to tizanidine, Baclofen is primarily used for spasticity in spinal cord injury patients or those with multiple sclerosis.

There are several muscle relaxers, or skeletal muscle relaxants. They include cyclobenzaprine (Flexeril), methocarbamol (Robaxin), and tizanidine (Zanaflex), among others. According to the American Academy of Family Physicians, there is no clear evidence that one is better or stronger than another.

Heart rhythm: Tizanidine can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death.

Tizanidine is in a class of medications called skeletal muscle relaxants. It works by slowing action in the brain and nervous system to allow the muscles to relax.

In patients with severe acute low-back pain, however, some sedation and bed rest is advantageous. This study shows that tizanidine/ibuprofen is more effective in the treatment of moderate or severe acute low-back pain than placebo and ibuprofen alone.

Tizanidine (EC50 = 0.125 ± 0.026 μg) was more potent than tramadol (EC50 = 16.45 ± 6.4 μg). The combination of tramadol-tizanidine at fixed ratios of 1:1 (EC50exp = 67.43 ± 11 μg; EC50teo = 8.28 ± 3.2 μg) and 3:1 (EC50exp = 31.25 ± 9.49 μg; CE50teo = 12.36 ± 4.8 μg) generated subadditivity (antagonism).

Will tizanidine knock you out?

82 patient evaluations for Tizanidine

Advice & Tips: Tizanidine can really knock you out. Wait until you're ready for bed before taking.

Some muscle relaxants (baclofen and tizanidine) can be used in older persons, again accounting for kidney and liver function. Opioids have limited use in common spine-related pain, but can be used with caution in cases that don't respond to treatment.

According to systematic reviews, almost all muscle relaxers are comparable in effectiveness. Cyclobenzaprine and tizanidine may be more sedating. However, cyclobenzaprine is one of the most studied muscle relaxers with strong evidence for its effectiveness.

If you get sore muscles once in a while, you can take acetaminophen or a nonsteroidal anti-inflammatory drug (NSAID) like aspirin, ibuprofen, or naproxen to help ease the discomfort. Just be cautious about using NSAIDs regularly.

COMMONLY USED MUSCLE RELAXANTS

This class of medications is well tolerated, with the most common side effects being drowsiness and nausea.

Tizanidine itself has a short “half-life” of only about 150 minutes, which means that the body clears the drug within a few hours.

Muscle relaxants used to treat muscle spasms and cramping normally don't increase blood pressure. In fact, they often lower it. As a result, muscle relaxers may not be safe to take with certain blood pressure medications.

What happens if you take tizanidine without food?

Switching between taking tizanidine with food and taking it without food can make the medicine less effective or cause increased side effects. Switching between tizanidine tablets and capsules may cause changes in side effects or how well the medicine works.

When you take the different dosage forms (tablets, capsules, capsule contents sprinkled over applesauce) of tizanidine with food, it affects the amount of the medicine absorbed into your blood differently. Follow your doctor's instructions for when to take this medicine and whether or not you should take it with food.

You are recommended to avoid taking caffeinated foods with TIZANIDINE as TIZANIDINE interacts with caffeine and cause severely low blood pressure and increase the risk of other adverse effects such as dizziness, irregular heartbeat, light-headedness, drowsiness, or fainting.

Additionally, the tizanidine/naproxen and tizanidine/ketorolac combinations showed anti-inflammatory and anti-nociceptive effects.

Nerve pain medication: Gabapentin (Neurontin) and pregabalin (Lyrica) may help reduce neck and back nerve pain, especially sciatica. Begin with low doses to avoid daytime drowsiness and fall risk. Muscle relaxants. Tizanidine (Zanaflex) and baclofen (Lioresal) may reduce pain from muscle spasms.

Clinicians should avoid co-prescribing tizanidine with strong CYP1A2 inhibitors, particularly in patients with higher comorbidity indices and in those who receive three or more antihypertensive agents.

Tizanidine should be used with special caution in patients receiving antihypertensive drugs. Renal dysfunction has not been reported as an adverse effect of tizanidine.

Moderate (for Overall) (weight gain, hair loss, dreams about teeth, worsening burning feeling at calves, feet & toes.)

You can take it with or without food. You should always take it the same way. Keep taking this medication unless your care team tells you to stop. Stopping it too quickly can cause serious side effects.

Based on their respective doses, tizanidine is slightly stronger. Based on their respective doses, tizanidine is slightly stronger. If Flexeril is not helping then by all means what is the difference between flexeril and zanaflex try a different medication.

What is one of the strongest muscle relaxers?

Carisoprodol. Carisoprodol helps alleviate musculoskeletal pain. It's a schedule IV drug (meaning it's a controlled substance) that is prone to abuse. While its potency usually sets within 30 minutes, its effectiveness is only known to last up to three weeks.

Is tizanidine better than cyclobenzaprine? Tizanidine may be preferred for muscle spasms caused by multiple sclerosis, cerebral palsy, and spinal cord injury. Cyclobenzaprine is used along with physical therapy and rest to relieve pain and muscle spasms.

Muscle relaxers: When the underlying cause of your sciatica is muscle spasms, muscle relaxers such as carisoprodol and cyclobenzaprine can provide relief. Tricyclic antidepressants: Doctors prescribe the anti-depressants amitriptyline and nortriptyline to reduce nerve pain.

Tizanidine reduces the activity of nerves in the spinal cord that control muscles. This helps to reduce muscle spasms.

Heart rhythm: Tizanidine can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death.

Ibuprofen 600mg mg + tizanidine 2-4mg every 8 hours, as needed for low back pain, x 7 days.

Tizanidine usually starts to work within one to two hours and wears off after about six to eight hours. This medicine can make you feel sleepy, dizzy, or weak. Be sure to take it at a time when you don't have to be alert.

We consider that tizanidine has direct effects on the induction of sleep, and promotes muscular relaxation bringing about good sleep. We conclude that tizanidine is useful for the treatment of refractory sleep disturbance in spastic quadriplegic patients.

Adults—At first, 2 milligrams (mg) every 6 to 8 hours. Your doctor may adjust your dose as needed. Do not take more than 36 mg within a 24-hour period. Children—Use and dose must be determined by your doctor.

Because tizanidine is extensively metabolized in the liver, hepatic impairment would be expected to have significant effects on pharmacokinetics of tizanidine [see DOSING AND ADMINISTRATION, WARNINGS AND PRECAUTIONS, and CLINICAL PHARMACOLOGY].

Does tizanidine harm your liver?

Tizanidine is a commonly used muscle relaxant that has been linked to rare instances of acute liver injury, a few of which have been fatal.

Considering that tizanidine increases the anti-inflammatory and anti-nociceptive effects of naproxen or ketorolac, with an increase in gastric tolerability, tizanidine could provide therapeutic advantages in the clinical treatment of inflammation and pain.