What beta blocker does not raise blood sugar?
The beta-blocker blood pressure medicine Coreg proved significantly better in keeping blood sugar levels from rising in diabetics than metaprolol, another widely used member of the beta-blocker family.
β Blockers are an important treatment for heart failure in patients whether or not they have diabetes,6 despite reported increases in blood glucose of up to 1.55 mmol/l,7 and HbA1c by as much as 1%.
Beta blockers may interfere with daily diabetes management in the following ways: Symptoms of having low blood sugar is a rapid heart beat, however, beta blockers actively work to lower the heart rate, potentially masking a key tell of dropping blood glucose levels.
Carvedilol has been found superior to metoprolol in the control of glucose metabolism in patients with type 2 diabetes and hypertension . Also studies show that carvedilol does not deteriorate insulin resistance, as it was found in a direct comparison with metoprolol .
They may also inhibit the release of glucose from the liver. But beta-blockers also block the release of insulin by interacting with nerve signals to the pancreas and can thus lower insulin levels even when blood glucose is high. There is some evidence that not all beta-blockers affect insulin secretion.
There are some conditions in which beta blockers are not recommended. This includes uncontrolled heart failure, hypotension (low blood pressure), certain problems with the rhythm of your heart, or bradycardia (a very slow heart beat).
This medicine may cause changes in blood sugar levels. Also, this medicine may cover up the symptoms of low blood sugar, including rapid pulse rate. Check with your doctor if you notice a change in your normal symptoms or a change in the results of your blood or urine sugar tests.
There were no significant changes in measures of insulin sensitivity, plasma lipids, or hemoglobin A1c with use of ER metoprolol.
Like non-selective beta blockers, metoprolol has been reported to increase fasting glucose concentrations and/or insulin concentrations and to decrease insulin sensitivity as measured by HOMA-IR.
Insulin secretion is inhibited by beta-blockers in vitro. However, no effect is seen in vivo in man. Hepatic glucose production in theory may be influenced, but no effect is demonstrable.
Do beta-blockers cause insulin resistance?
Specifically, β blockers, in general, worsen insulin resistance and increase triglycerides in a dose-dependent fashion. Moreover, they are not recommended as initial therapy for hypertension treatment in the absence of heart failure or recent myocardial infarction, especially in the elderly.
The mechanism responsible for β-blocker–induced hypoglycemia involves inhibition of hepatic glucose production, which is promoted by sympathetic nervous stimulation. In addition, adrenergic counterregulation is diminished, resulting in a reduction in glycogenolysis.
Beta blocker use is associated with increased odds of hypoglycemia among hospitalized patients not requiring basal insulin, and odds are greater for selective beta blockers than for carvedilol.
Moreover, all beta-blockers significantly inhibited OCT2-mediated metformin uptake (IC(50) for bisoprolol: 2.4 microM, IC(50) for carvedilol: 2.3 microM, IC(50) for metoprolol: 50.2 microM and IC(50) for propranolol: 8.3 microM).
Hydrochlorothiazide and chlorthalidone
Hydrochlorothiazide (HCTZ) and chlorthalidone are diuretics used to lower blood pressure but may increase your risk for high blood sugar and diabetes.
Medicines That Increase Blood Sugar:
Antidepressants (Zyprexa, risperdal, Clozaril, Seroquel, Abilify, Geodon, lithium) Beta-2 stimulators (Proventil, Alupent, Serevent, Foradil, Brethine, Theo-Dur) Caffeine. Corticosteroids (Prednisone, Decadron, DepoMedrol)
Side effects commonly reported by people taking beta blockers include: feeling tired, dizzy or lightheaded (these can be signs of a slow heart rate) cold fingers or toes (beta blockers may affect the blood supply to your hands and feet) difficulties sleeping or nightmares.
How long can I stay on beta-blockers? You can use beta-blockers for extended periods. In some cases, especially for adults over 65, it's possible to use them for years or indefinitely.
Based on research studies, there are three beta blockers that are best for heart failure: carvedilol, metoprolol succinate (the long-acting form of metoprolol), and bisoprolol. These beta blockers have been shown to lower your risk of dying from heart failure complications.
Metoprolol may worsen the symptoms of heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing or heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain.
Can blood pressure medicine mess with your blood sugar?
Beta-Blockers for Conditions Such as Arrhythmia and Anxiety. This large class of drugs is used to lower blood pressure and treat a variety of other conditions, including irregular heartbeat and anxiety, but they can also raise your blood sugar levels.
This medication is a beta-blocker used to treat chest pain (angina), heart failure, and high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Glipizide (sulfonylurea class)
When combined with insulin, glipizide causes severe hypoglycemia, which should be avoided. The drug has been shown to reduce A1C levels by 1% to 2% and works best when taken 30 minutes before a meal.
Interactions between your drugs
Beta-blockers such as metoprolol may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar) in patients receiving insulin regular and certain other antidiabetic medications.
Beta-blockers have no impact on survival in pancreatic ductal adenocarcinoma prior to cancer diagnosis | Scientific Reports.